For a complete list of publications, please visit PubMed.gov.

Representative publications

  1. Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism.

    Xin Yang, Zhe Wang, Fereshteh Zandkarimi, Yanqing Liu, Shoufu Duan, Zhiming Li, Ning Kon, Zhiguo Zhang, Xuejun Jiang, Brent R Stockwell, Wei Gu.

    Cell Metab. 2023.

    doi: 10.1016/j.cmet.2023.06.014.

  2. Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism.

    Zhenyi Su, Ning Kon, Jingjie Yi, Haiqing Zhao, Wanwei Zhang, Qiaosi Tang, Huan Li, Hiroki Kobayashi, Zhiming Li, Shoufu Duan, Yanqing Liu, Kenneth P Olive, Zhiguo Zhang, Barry Honig, James J Manfredi, Anil K Rustgi, Wei Gu.

    Nature Cancer. 2023

    doi: 10.1038/s43018-023-00532-z.

  3. ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway
    Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W
    Nat Cell Biol. 2019.
    doi: 10.1038/s41556-019-0305-6. PMID: 30962574

  4. NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
    Chen D, Tavana O, Chu B, Erber L, Chen Y, Baer R, Gu W
    Mol Cell. 2017.
    doi: 10.1016/j.molcel.2017.09.009. PMID: 28985506

  5. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode
    Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu WG, Qin J, Honig B, Gu W
    Nature. 2016.
    doi: 10.1038/nature19759. PMID: 27626385

  6. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
    Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, Chen C, Califano A, Yamashiro DJ, Sun H, Gu W
    Nat Med. 2016.
    doi: 10.1038/nm.4180. PMID: 27618649

  7. Ferroptosis as a p53-mediated activity during tumour suppression
    Jiang L, Kon N, Li T, Wang SJ, Su T, Hibshoosh H, Baer R, Gu W
    Nature. 2015.
    doi: 10.1038/nature14344. PMID: 25799988

  8. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence
    Li T, Kon N, Jiang L, Tan M, Ludwig T, Zhao Y, Baer R, Gu W
    Cell. 2012.
    doi: 10.1016/j.cell.2012.04.026. PMID: 22682249

  9. Acetylation is indispensable for p53 activation.

    Tang Y, Zhao W, Chen Y, Zhao Y, Gu W.

    Cell. 2008 May 16;133(4):612-26.

    doi: 10.1016/j.cell.2008.03.025. PMID: 18485870

  10. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
    Chen D, Shan J, Zhu WG, Qin J, Gu W
    Nature. 2010.
    doi: 10.1038/nature08820. PMID: 20208519

  11. Modes of p53 regulation
    Kruse JP, Gu W
    Cell. 2009.
    doi: 10.1016/j.cell.2009.04.050. PMID: 19450511

  12. Negative regulation of the deacetylase SIRT1 by DBC1
    Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W
    Nature. 2008.
    doi: 10.1038/nature06515. PMID: 18235502

  13. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
    Chen D, Kon N, Li M, Zhang W, Qin J, Gu W
    Cell. 2005.
    doi: 10.1016/j.cell.2005.03.037. PMID: 15989956

  14. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2
    Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W
    Science. 2003.
    doi: 10.1126/science.1091362. PMID: 14671306

  15. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
    Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W
    Nature. 2002.
    doi: 10.1038/nature737. PMID: 11923872

  16. Negative control of p53 by Sir2alpha promotes cell survival under stress
    Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W
    Cell. 2001.
    doi: 10.1016/s0092-8674(01)00524-4. PMID: 11672522

  17. Deacetylation of p53 modulates its effect on cell growth and apoptosis
    Luo J, Su F, Chen D, Shiloh A, Gu W
    Nature. 2000.
    doi: 10.1038/35042612. PMID: 11099047