2010

  1. Reactivating the ARF-p53 axis in AML cells by targeting ULF.

    Chen D, Yoon JB, Gu W.

    Cell Cycle. 2010.

    doi: 10.4161/cc.9.15.12355. PMID: 20699639

  2. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.

    Chen D, Shan J, Zhu WG, Qin J, Gu W.

    Nature. 2010.

    doi: 10.1038/nature08820. PMID: 20208519

  3. Targeting the degradation of cyclin D1 will help to eliminate oncogene addiction.

    Lee JT, Shan J, Gu W.

    Cell Cycle. 2010.

    doi: 10.4161/cc.9.5.11175. PMID: 20160484

  4. The multiple levels of regulation by p53 ubiquitination.

    Lee JT, Gu W.

    Cell Death Differ. 2010.

    doi: 10.1038/cdd.2009.77. PMID: 19543236

  5. Inactivation of HAUSP in vivo modulates p53 function.

    Kon N, Kobayashi Y, Li M, Brooks CL, Ludwig T, Gu W.

    Oncogene. 2010.

    doi: 10.1038/onc.2009.427. PMID: 19946331

2009

  1. Suppression of cancer cell growth by promoting cyclin D1 degradation.

    Shan J, Zhao W, Gu W.

    Mol Cell. 2009.

    doi: 10.1016/j.molcel.2009.10.018. PMID: 19917254

  2. Anti-aging protein SIRT1: a role in cervical cancer?

    Brooks CL, Gu W.

    Aging (Albany NY). 2009.

    doi: 10.18632/aging.100031. PMID: 20157516

  3. MSL2 promotes Mdm2-independent cytoplasmic localization of p53.

    Kruse JP, Gu W.

    J Biol Chem. 2009.

    doi: 10.1074/jbc.M805658200. PMID: 19033443

2008

  1. SirT1 gain of function increases energy efficiency and prevents diabetes in mice.

    Banks AS, Kon N, Knight C, Matsumoto M, Gutiérrez-Juárez R, Rossetti L, Gu W, Accili D.

    Cell Metab. 2008.

    doi: 10.1016/j.cmet.2008.08.014. PMID: 18840364

  2. SnapShot: p53 posttranslational modifications.

    Kruse JP, Gu W.

    Cell. 2008.

    doi: 10.1016/j.cell.2008.05.020. PMID: 18510935

  3. Acetylation is indispensable for p53 activation.

    Tang Y, Zhao W, Chen Y, Zhao Y, Gu W.

    Cell. 2008.

    doi: 10.1016/j.cell.2008.03.025. PMID: 18485870

  4. p53 Activation: a case against Sir.

    Brooks CL, Gu W.

    Cancer Cell. 2008.

    doi: 10.1016/j.ccr.2008.04.009. PMID: 18455119

  5. Negative regulation of the deacetylase SIRT1 by DBC1.

    Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W.

    Nature. 2008.

    doi: 10.1038/nature06515. PMID: 18235502

  6. p53-Dependent and p53-independent activation of autophagy by ARF.

    Abida WM, Gu W.

    Cancer Res. 2008.

    doi: 10.1158/0008-5472.CAN-07-2069. PMID: 18199527

2007

  1. Non-transcriptional control of DNA replication by c-Myc.

    Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R.

    Nature. 2007.

    doi: 10.1038/nature05953. PMID: 17597761

  2. The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

    Brooks CL, Li M, Hu M, Shi Y, Gu W.

    Oncogene. 2007.

    doi: 10.1038/sj.onc.1210531. PMID: 17525743

  3. Mechanistic studies of MDM2-mediated ubiquitination in p53 regulation.

    Brooks CL, Li M, Gu W.

    J Biol Chem. 2007.

    doi: 10.1074/jbc.M700961200. PMID: 17500067

  4. Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis.

    Tang Y, Luo J, Zhang W, Gu W.

    Mol Cell. 2006.

    doi: 10.1016/j.molcel.2006.11.021. PMID: 17189186

  5. FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.

    Abida WM, Nikolaev A, Zhao W, Zhang W, Gu W.

    J Biol Chem. 2007.

    doi: 10.1074/jbc.M609001200. PMID: 17098746

2006

  1. p53 aerobics: the major tumor suppressor fuels your workout.

    Kruse JP, Gu W.

    Cell Metab. 2006.

    doi: 10.1016/j.cmet.2006.06.004. PMID: 16814724

  2. ARF-BP1 as a potential therapeutic target.

    Chen D, Brooks CL, Gu W.

    Br J Cancer. 2006.

    doi: 10.1038/sj.bjc.6603119. PMID: 16641901

2005

  1. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.

    Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D.

    Cell Metab. 2005.

    doi: 10.1016/j.cmet.2005.08.004. PMID: 16154098

  2. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.

    Chen D, Kon N, Li M, Zhang W, Qin J, Gu W.

    Cell. 2005.

    doi: 10.1016/j.cell.2005.03.037. PMID: 15989956

2004

  1. Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex.

    Nikolaev AY, Papanikolaou NA, Li M, Qin J, Gu W.

    Biochem Biophys Res Commun. 2004.

    doi: 10.1016/j.bbrc.2004.08.227. PMID: 15451426

  2. Monoubiquitination: the signal for p53 nuclear export?

    Brooks CL, Li M, Gu W.

    Cell Cycle. 2004.

    doi.org/10.4161/cc.3.4.782. PMID: 14976431

  3. A dynamic role of HAUSP in the p53-Mdm2 pathway.

    Li M, Brooks CL, Kon N, Gu W.

    Mol Cell. 2004.

    doi: 10.1016/s1097-2765(04)00157-1. PMID: 15053880

  4. Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo.

    Luo J, Li M, Tang Y, Laszkowska M, Roeder RG, Gu W.

    Proc Natl Acad Sci USA. 2004.

    doi: 10.1073/pnas.0308762101. PMID: 14982997

2003

  1. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

    Li M, Brooks CL, Wu-Baer F, Chen D, Baer R, Gu W.

    Science. 2003.

    doi: 10.1126/science.1091362. PMID: 14671306

  2. PARC: a potential target for cancer therapy.

    Nikolaev AY, Gu W.

    Cell Cycle. 2003.

    doi.org/10.4161/cc.2.3.346. PMID: 12734414

  3. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function.

    Chen D, Li M, Luo J, Gu W.

    J Biol Chem. 2003.

    doi: 10.1074/jbc.C200694200. PMID: 12606552

  4. Parc: a cytoplasmic anchor for p53.

    Nikolaev AY, Li M, Puskas N, Qin J, Gu W.

    Cell. 2003.

    doi: 10.1016/s0092-8674(02)01255-2. PMID: 12526791

2000-2002

  1. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.

    Hu M, Li P, Li M, Li W, Yao T, Wu JW, Gu W, Cohen RE, Shi Y.

    Cell. 2002.

    doi: 10.1016/s0092-8674(02)01199-6. PMID: 12507430

  2. Acetylation of p53 inhibits its ubiquitination by Mdm2.

    Li M, Luo J, Brooks CL, Gu W.

    J Biol Chem. 2002.

    doi: 10.1074/jbc.C200578200. PMID: 12421820

  3. Acetylation inactivates the transcriptional repressor BCL6.

    Bereshchenko OR, Gu W, Dalla-Favera R.

    Nat Genet. 2002.

    doi: 10.1038/ng1018. PMID: 12402037

  4. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization.

    Li M, Chen D, Shiloh A, Luo J, Nikolaev AY, Qin J, Gu W.

    Nature. 2002.

    doi: 10.1038/nature737. PMID: 11923872

  5. Negative control of p53 by Sir2alpha promotes cell survival under stress.

    Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W.

    Cell. 2001.

    doi: 10.1016/s0092-8674(01)00524-4. PMID: 11672522

  6. Deacetylation of p53 modulates its effect on cell growth and apoptosis.

    Luo J, Su F, Chen D, Shiloh A, Gu W.

    Nature. 2000.

    doi: 10.1038/35042612. PMID: 11099047

  7. Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex.

    Skowyra D, Zeremski M, Neznanov N, Li M, Choi Y, Uesugi M, Hauser CA, Gu W, Gudkov AV, Qin J.

    J Biol Chem. 2001.

    doi: 10.1074/jbc.M007664200. PMID: 11118440

  8. The function of PML in p53-dependent apoptosis.

    Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP.

    Nat Cell Biol. 2000.

    doi: 10.1038/35036365. PMID: 11025664

  9. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs.

    Malik S, Gu W, Wu W, Qin J, Roeder RG.

    Mol Cell. 2000.

    doi: 10.1016/s1097-2765(00)80254-3. PMID: 10882111